Resistant duodenal ulcer: when, why and what to do?

نویسندگان

  • R P Walt
  • T K Daneshmend
چکیده

Duodenal ulceration is a chronic disease the causes of which remain unknown. Current medical treatment interrupts the natural history and accelerates ulcer healing. It does not cure ulcers. All duodenal ulcers are generally considered together even though pathophysiological mechanisms differ from patient to patient. It should not be surprising that some duodenal ulcer patients respond relatively poorly. However, duodenal ulcers which do not heal in the 'usual' time have traditionally been labelled as difficult, refractory, intractable, stubborn, recalcitrant, persistent, or resistant. There is no agreement on the definition of resistance and such patients may merely represent one extreme of the 'normal' ulcer population. For the purposes of this article, our definition of resistant duodenal ulcer is: The failure of a duodenal ulcer to heal after two months of full-dose treatment with an H2-receptor antagonist.

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عنوان ژورنال:
  • Postgraduate medical journal

دوره 64 751  شماره 

صفحات  -

تاریخ انتشار 1988